Premarin

The drug is an innovative estrogenic means which regulates the change and preservation of the activity of the female restorative system, the growth of sexual differences in women.

Product description

Getting into the blood system the remedy creates a complex with specific receptors, activates the synthesis of DNA and proteins. In this case, there is a proliferation of the upper layer of the skin. The cure increases the sensitivity of the uterine muscles and tubes to excite their motility.

It weakens bone resorption of Ca2+ during a midlife crisis, eliminates the involution of the genitals. It has a hypolipidemic effect, lowers the concentration of LDL in the blood, increases-HDL, susceptibility to insulin, improves glucose processing; activates the production of liver globulins binding sex hormones - renin and blood clotting factors; affects the metabolism of Ca2+ and phosphorus (helps to preserve the normal structure of bones, partly contributes to the growth of the skeleton and its final formation).

In large doses, the medicine inhibits water and Na+ in the body, delays erythropoiesis. Due to participation in the implementation of positive and negative reaction in the system, the substance causes restrained central effects. It eliminates expression of the climacteric syndrome: a feeling of heat, increased sweating, dizziness, irritability, depression; cancel the beginning of osteoporosis after a menopause. The remedy also supports the normalization of menstruation in women. As for men, it lowers testosterone levels.

Safety information

During the cure by this drug, one should know about the risk of cancer growth in the postmenopausal period. Before starting to use it, it is indispensable to perform an accurate medical and gynecological diagnosis.These studies should be performed every half year. To reduce the risk of hyperplasia or endometrial cancer the patients with an intact uterus are prescribed gestagens from ten to the fourteenth day of the menstrual cycle. If treatment with gestagens is not carried out, a gynecological test with a mandatory biopsy of the endometrium is indicated. Information on the likelihood of breast cancer in postmenopausal in women with estrogen therapy is debatable.

There is a point of view that the use of large doses or long-term treatment for more than ten years makes the risk of breast cancer more probable. However, in our time, the vast majority of researchers believe this fact is unproven. Women receiving estrogen replacement treatment should constantly conduct a survey of the female breast and should be trained in the skills of their self-examination. There are reports of an increased risk of gallbladder disease in women who use postmenopausal estrogen. Estrogens accelerate the process of epiphyseal ossification; therefore they should not be used by children and adolescents during their period of the intense growth.

Side Effects

In females, the medicine provokes weakness, increased breast size, amenorrhea, bleeding. Men have weakness and sensitivity of the breast, gynecomastia, decreased libido. Peripheral edema, vomiting, diarrhea, dizzy, headache (including a migraine), inability to wear contact lenses, vomiting (mainly in the application of large doses). During the treatment of breast and prostate cancer (in addition): thromboembolism, thrombosis.